What it does / how it works
A triple agonist: GIP, GLP-1 and glucagon receptors. GLP-1/GIP handle appetite and insulin. The glucagon arm raises energy use and liver fat burn, which is also why GI effects and heart rate can run hotter than dual agonists.
| Class | GIP / GLP-1 / glucagon triple agonist |
| Typical vial | 5–100 mg |
| Reconstitution | 1–2 mL BAC water |
| Storage after mix | 2–8°C, use within 28 days |
Protocol
| Goal | Dose | How often | How long | Route |
| Weeks 1-4 | 2 mg | Once weekly | 4 weeks | SubQ |
| Weeks 5-8 | 4 mg | Once weekly | 4 weeks | SubQ |
| Weeks 9-12 | 8 mg | Once weekly | 4 weeks | SubQ |
| Week 13 on | 8 or 12 mg | Once weekly | Up to 48 weeks in Phase 2 | SubQ |
Watch: No approved label. Skin tingling was more common than with dual agonists.