What it does / how it works
Amylin fullness plus GLP-1 fullness. That is the CagriSema idea. Two nausea pathways, so the climb is weekly and slow.
| Class | Blend · CS5 = 2.5+2.5 mg · CS10 = 5+5 mg |
| Typical vial | 5 or 10 mg total |
| Reconstitution | CS5: 1 mL BAC = 2.5 mg/mL of each. |
| Storage after mix | 2–8°C, use within 28 days |
Protocol
| Goal | Dose | How often | How long | Route |
| Weeks 1-4 | Cagrilintide 0.30 mg + Semaglutide 0.30 mg | Once weekly | 4 weeks | SubQ |
| Weeks 5-8 | Cagrilintide 0.60 mg + Semaglutide 0.60 mg | Once weekly | 4 weeks | SubQ |
| Goal | Dose | How often | How long | Route |
| Weeks 9-12 | Cagrilintide 1.20 mg + Semaglutide 1.20 mg | Once weekly | 4 weeks | SubQ |
| REDEFINE target | Cagrilintide 2.4 mg + Semaglutide 2.4 mg | Once weekly | 68 weeks in Phase 3 | SubQ |
| Do not start here | 5 mg + 5 mg | Once weekly | Not a start dose | SubQ |
Watch: Additive nausea. Hold the dose instead of jumping vial size.