For research use only. Not for human consumption.

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Semaglutide

A highly purified, long-acting GLP-1 receptor agonist designed for research into glucose-dependent insulin regulation, gastric motility, and neurological appetite pathways.

Price range: $50.00 through $110.00

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How Semaglutide Works

Semaglutide operates as a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist. It shares a 94% structural homology with native human GLP-1, modified specifically to resist enzymatic degradation by dipeptidyl peptidase-4 (DPP-4), thereby significantly extending its biological half-life in laboratory settings.

In research and clinical environments, the compound targets GLP-1 receptors across three primary therapeutic axes:

  • Pancreatic and Glycemic Regulation: Semaglutide binds to pancreatic beta-cells to stimulate glucose-dependent insulin secretion. Simultaneously, it suppresses alpha-cell glucagon secretion, lowering hepatic glucose output and preventing sharp postprandial glucose spikes.

  • Gastric Motility: The compound delays gastric emptying. By slowing down the rate at which nutrients are processed through the gastrointestinal tract, it modulates early digestion dynamics.

  • Neurological Appetite Control: Semaglutide crosses the blood-brain barrier to interact directly with the arcuate nucleus of the hypothalamus. It upregulates anorexigenic (satiety-inducing) pathways while downregulating orexigenic (hunger-stimulating) signaling, leading to a profound reduction in caloric demand and systemic appetite suppression.

Chemical Properties

Property Details
Product Name Semaglutide
Compound Type Synthetic Lipopeptide / GLP-1 Receptor Agonist
Core Components A linear sequence of 31 amino acids modified with an Aib substitution at position 8, an Arg substitution at position 34, and a C-18 fatty acid di-acid chain acylated via a hydrophilic spacer to Lysine-26.
Purity Standard ≥98.0% (Typically verified via High-Performance Liquid Chromatography / Mass Spectrometry)
Appearance Lyophilized white to off-white solid cake/powder (reconstitutes into a clear, colorless solution)
pH Range ~7.4 when reconstituted in sterile physiological buffers or bacteriostatic diluents
Storage (Unopened Lyophilized Solid) Store at -20°C to 4°C (Stable for up to 24–36 months; must be protected from direct UV light and moisture)
Storage (Reconstituted Liquid) Store at 2°C to 8°C (Refrigerated). Potency degrades rapidly if exposed to temperatures exceeding 30°C (86°F) or if subjected to mechanical freezing.
Intended Use Laboratory Research Applications Only

Additional information

Dosage

10MG, 15MG, 20MG, 2MG, 30MG, 5MG

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