For research use only. Not for human consumption.
( 5.0 Ratings )
A highly potent 10-amino acid decapeptide fragment designed for research into central HPG axis activation, pulsed GnRH secretion, luteinizing hormone release, and neuroendocrine reproductive control.
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Kisspeptin-10 is the minimal, fully functional carboxyl-terminal fragment of the parent Kisspeptin-54 protein (encoded by the KISS1 gene). Acting at the top of the reproductive signaling cascade, Kisspeptin-10 serves as the master switch for the Hypothalamic-Pituitary-Gonadal (HPG) axis:
KISS1R Receptor Agonism: Kisspeptin-10 acts as a potent, high-affinity agonist at the KISS1R (formerly GPR54) G-protein-coupled receptor, located directly on Gonadotropin-Releasing Hormone (GnRH) neurons in the hypothalamus.
Stimulation of Pulsatile GnRH: Upon binding to KISS1R, Kisspeptin-10 triggers a rapid influx of intracellular calcium, causing GnRH neurons to release pulses of GnRH into the hypophyseal portal circulation.
Downstream LH & FSH Release: The pulsed release of GnRH travels to the anterior pituitary gland, signaling the immediate secretion of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH), which in turn drive endogenous sex steroid synthesis (testosterone and estrogen).
Reproductive & Behavioral Modulation: Beyond gonadotropin secretion, kisspeptin pathways intersect with limbic brain networks, making Kisspeptin-10 a valuable tool for researching sexual behavior, mood regulation, and metabolic interactions with fertility.
| Property | Details |
| Product Name | Kisspeptin-10 (KISS-10 / Metastatin 45-54) |
| Compound Type | Endogenous Decapeptide / KISS1R Agonist |
| Purity Standard | 98% or higher purity (verified by HPLC / Mass Spectrometry) |
| Appearance | Fine white lyophilized powder (dissolves cleanly into aqueous solutions) |
| pH Range | Formulated to sit between ~5.5–7.0 when reconstituted in standard laboratory buffers |
| Storage (Unopened Powder) | Store in the freezer or fridge (-20°C to 4°C). Keep protected from light and moisture. Stable for 2–3 years. |
| Storage (Mixed Liquid) | Must be stored immediately in the fridge (2°C to 8°C). Highly delicate structure; avoid heat, direct light, and freeze-thaw cycles. |
| Intended Use | Laboratory Research Only |
| Dosage | 10MG, 5MG |
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