How 5-Amino-1MQ Works

5-Amino-1MQ is a selective small-molecule inhibitor of Nicotinamide N-methyltransferase (NNMT), an enzyme primarily active in fat tissue and the liver that plays a major role in regulating cellular energy usage:

• NNMT Enzyme Inhibition: By blocking the NNMT enzyme, 5-Amino-1MQ prevents the breakdown and loss of key energy cofactors inside cells, effectively increasing intracellular levels of NAD+ and SAM (S-adenosylmethionine).

• Accelerated Fat Metabolism: Inhibiting NNMT triggers fat cells (adipocytes) to shrink by boosting their baseline metabolic rate and forcing them to burn energy rather than store it as fat tissue.

• Elevated Cellular Energy & NAD+: Higher cellular NAD+ levels promote healthier mitochondrial function, enhancing cellular power production and cellular repair mechanisms.

• Preservation of Lean Mass: Researched for its ability to target metabolic energy waste in fat cells while preserving muscle tissue during calorie-restricted conditions.

Chemical Properties