What it does / how it works
A long-acting copy of amylin, the hormone co-released with insulin. It slows gastric emptying, increases fullness and works on brain satiety centres. Stacked with a GLP-1, the two fullness signals add up.
| Class | Long-acting amylin analogue |
| Typical vial | 5 or 10 mg |
| Reconstitution | 1–2 mL BAC water per 5 mg |
| Storage after mix | 2–8°C, use within 28 days |
Protocol
| Goal | Dose | How often | How long | Route |
| Weeks 1-4 | 0.3 mg | Once weekly | 4 weeks | SubQ |
| Weeks 5-8 | 0.6-1.2 mg | Once weekly | 4 weeks | SubQ |
| Weeks 9-12 | 2.4 mg | Once weekly | 4 weeks | SubQ |
|
Week 13 on |
2.4 mg usual target, 4.5 mg was highest Phase 2 arm |
Once weekly |
26 weeks in Phase 2 |
SubQ |
Watch: Nausea stacks with GLP-1 nausea. Titrate both if combined.